Axonal Pushing Theory of Cortical Folding

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Research Theme:

Axonal Pushing Theory of Cortical Folding.

Introduction:

Cortical folding and structural axonal fiber wiring are two prominent attributes of the cerebral cortex in primate brains. However, the intrinsic relationships between cortical folding and structural connection across primates remain unclear. Our qualitative and quantitative analyses consistently demonstrate that structural fiber connection pattern closely follows gyral folding pattern in both vertical direction and tangent direction to the cortical sphere. These findings suggest a hypothesis that axonal fiber pushing mechanism sculpts the curved patterns of gyri and sulci during primate brain development and evolution.

This theme of research aims to dissect the structural and functional connections between cortical gyri and sulci, and establish a fundamental theoretic framework that can consistently explain the intrinsic relationships amongst cortical folding patterns, structural connections, and functional interactions between gyri and sulci in primate cortices.

Representative Publications:

Xi Jiang, Xiang Li, Jinglei Lv, Shijie Zhao, Shu Zhang, Wei Zhang, Tuo Zhang, Junwei Han, Lei Guo, Tianming Liu, Temporal Dynamics Assessment of Spatial Overlap Pattern of Functional Brain Networks Reveals Novel Functional Architecture of Cerebral Cortex, IEEE Transactions on Biomedical Engineering, 2016. in press. PDF

Gang Li, Tianming Liu, Dong Ni, Weili Lin, John H. Gilmore, Dinggang Shen, Spatiotemporal Patterns of Cortical Fiber Density in Developing Infants, and Their Relationship with Cortical Thickness, Human Brain Mapping, 2015. vol. 36(12), pp. 5183-5195.PDF

Xi Jiang, Xiang Li, Jinglei Lv, Tuo Zhang, Shu Zhang, Lei Guo, Tianming Liu, Sparse Representation of HCP Grayordinate Data Reveals Novel Functional Architecture of Cerebral Cortex, Human Brain Mapping, 2015. vol. 36(12), pp. 5301-5319.PDF

Tao Zeng, Hanbo Chen, Ahmed Fakhry, Xiaoping Hu, Tianming Liu*, Shuiwang Ji*, Allen Mouse Brain Atlases Reveal Different Neural Connection and Gene Expression Patterns in Cerebellum Gyri and Sulci, Brain Structure and Function, 2015. vol. 220(5), pp. 2691-703. *Joint-correspondence authors.PDF

Tuo Zhang, Hanbo Chen, Lei Guo, Kaiming Li, Longchuan Li, Shu Zhang, Dinggang Shen, Xiaoping Hu, Tianming Liu, Characterization of U-shape Streamline Fibers: Methods and Applications, Medical Image Analysis, 2014. vol. 18(5), pp. 795-807. PDF

Fan Deng, Xi Jiang, Dajiang Zhu, Tuo Zhang, Kaiming Li, Lei Guo, Tianming Liu, A functional model of cortical gyri and sulci, Brain Structure and Function, 2013. vol. 219(4), pp. 1473-91.PDF

Hanbo Chen*, Tuo Zhang*, Lei Guo, Kaiming Li, Xiang Yu, Longchuan Li, Xintao Hu, Junwei Han, Xiaoping Hu**, Tianming Liu**, Coevolution of Gyral Folding and Structural Connection Patterns in Primate Brains, Cerebral Cortex, 2013. vol. 23(5), pp. 1208-1217. *Joint first authors, **Joint corresponding authors.PDF

Jingxin Nie, Lei Guo, Kaiming Li, Yonghua Wang, Guojun Chen, Longchuan Li, Hanbo Chen, Fan Deng, Xi Jiang, Tuo Zhang, Ling Huang, Carlos Faraco, Degang Zhang, Cong Guo, Pew-Thian Yap, Xintao Hu, Gang Li, Jinglei Lv, Yixuan Yuan, Dajiang Zhu, Junwei Han, Dean Sabatinelli, Qun Zhao, L Stephen Miller, Bingqian Xu, Ping Shen, Simon Platt, Dinggang Shen, Xiaoping Hu, Tianming Liu, Axonal Fiber Terminations Concentrate on Gyri, Cerebral Cortex, 2012. vol. 22(12), pp. 2831-2839.PDF

Kaiming Li, Lei Guo, Gang Li, Jingxin Nie, Carlos Faraco, Guangbin Cui, Qun Zhao, Stephen Miller, Tianming Liu, Gyral folding pattern analysis via surface profiling, NeuroImage, 52(4):1202–14, 2010.PDF

Related Methodological and Algorithmic Publications:

Jingxin Nie, Lei Guo, Gang Li, Carlos Faraco, Stephen Miller, Tianming Liu, A computational model of cerebral cortex folding, Journal of Theoretical Biology, 264(2):467-78, 2010.PDF

Gang Li, Lei Guo, Jingxin Nie, Tianming Liu, An Automated Pipeline for Cortical Sulcal Fundi Extraction, Medical Image Analysis, Volume 14, Issue 3, Pages 343-359, 2010.PDF

Gang Li, Lei Guo, Jingxin Nie, Tianming Liu, Automatic cortical sulcal parcellation based on surface principal direction flow field tracking, Neuroimage, 46(4):923-37 2009.PDF

Tianming Liu, Jingxin Nie, Ashley Tarokh, Lei Guo, Stephen TC Wong, Reconstruction of central cortical surface from brain MRI images: Method and application. NeuroImage, 15, 40(3):991-1002, 2007.PDF

Tianming Liu, Hai Li, Kelvin Wong, Ashley Tarokh, Lei Guo, Stephen Wong, Brain tissue segmentation based on DTI data, NeuroImage, 38(1):114-23, 2007.PDF

Tianming Liu, Geoffrey Young, Ling Huang, Nan-Kuei Chen, Stephen Wong. 76-Space analysis of grey matter diffusivity: Methods and applications. Neuroimage. 2006, 15(31):51-65.PDF

Tianming Liu, Dinggang Shen, and Christos Davatzikos. Deformable registration of cortical structures via hybrid volumetric and surface warping. NeuroImage. 2004, 22(4):1790-801.PDF